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Article

PARKINInactivation Links Parkinson’s Disease to Melanoma

17 Dec 2015

Abstract excerpt

BACKGROUND: Melanoma incidence is higher in patients affected by Parkinson's disease (PD) and vice versa, but the genetic link shared by both diseases is unknown. As PARK2 is both a tumor suppressor gene and frequently mutated in young onset PD, we evaluated the role of PARK2 in melanoma predisposition and progression. METHODS: An in-depth PARK2 gene dosage analysis and sequencing was performed on 512 French case...

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Share to Cutaneous Melanoma Detection and Management
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Share to Parkinson's Disease Mechanisms and Treatments

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PMID: 26683220
DOI: 10.1093/jnci/djv340

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