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Article

HLA-E monoclonal antibodies recognize shared peptide sequences on classical HLA class Ia: relevance to human natural HLA antibodies.

Molecular immunology - 1 Feb 2010

Ravindranath Mepur H, Taniguchi Michiko, Chen Chien-wei, Ozawa Miyuki, Kaneku Hugo, El-Awar Nadim, Cai Junchao, Terasaki Paul I

Abstract excerpt

The non-classical HLA-Ib molecule, HLA-E share several peptide sequence similarities with the heavy chains of classical HLA class Ia (-B and -C) molecules. Therefore, the antibodies to HLA-E, that recognize shared sequences, may bind to HLA-Ia alleles. This hypothesis is tested by examining the affinity of HLA-E monoclonal antibodies (HLA-E-MAbs) to HLA-Ia molecules and by inhibiting the antibody binding to both...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta 2-Microglobulin

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Share to Histocompatibility Antigens Class I

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Source

Identifiers

PMID: 19944464
DOI: 10.1016/j.molimm.2009.10.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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