Article
Antibodies to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2010
Ravindranath Mepur H, Kaneku Hugo, El-Awar Nadim, Morales-Buenrostro Luis E, Terasaki Paul I
Abstract excerpt
Natural anti-HLA Abs found in sera of healthy nonalloimmunized males recognize HLA-Ia alleles parallel to those recognized by anti-HLA-E mAbs (MEM-E/02/06/07). Therefore, some of the HLA-Ia Abs seen in healthy males could be due to anti-HLA-E Abs cross-reacting with HLA-Ia. If anti-HLA-E Abs occur in healthy nonalloimmunized males, it can be assessed whether they evoke HLA-Ia reactivity as do mouse HLA-E mAbs....
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