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Article

Therapeutic preparations of IVIg contain naturally occurring anti-HLA-E antibodies that react with HLA-Ia (HLA-A/-B/-Cw) alleles.

Blood - 14 Mar 2013

Ravindranath Mepur H, Terasaki Paul I, Pham Tho, Jucaud Vadim, Kawakita Satoru

Abstract excerpt

The US Food and Drug Administration approved intravenous immunoglobulin (IVIg), extracted from the plasma of thousands of blood donors, for removing HLA antibodies (Abs) in highly sensitized patients awaiting organ transplants. Since the blood of healthy individuals has HLA Abs, we tested different IVIg preparations for reactivity to HLA single antigen Luminex beads. All preparations showed high levels of HLA-Ia...

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Share to Antibodies
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Share to HLA-A Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B Antigens

Share to HLA-C Antigens

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Share to Immunoglobulins, Intravenous

Source

Identifiers

PMID: 23305735
DOI: 10.1182/blood-2012-08-447771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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