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Article

Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins.

Biochemical and biophysical research communications - 1 Jan 2010

Massariol Marie-Josée, Zhao Songping, Marquis Martin, Thibeault Diane, White Peter W

Abstract excerpt

The bifunctional NS3 protease-helicase of hepatitis C virus (HCV), together with its cofactor protein NS4A, is an important target for antiviral drugs which can cure HCV infections. HCV strains are divided into six major genotypes based on sequence diversity, and the great majority of reports on NS3 have focused exclusively on genotype 1 proteins. Here we report the cloning, expression, and preliminary...

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Identifiers

PMID: 19944069
DOI: 10.1016/j.bbrc.2009.11.122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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