Article
Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.
The Biochemical journal - 1 Sept 2001
Kikkert M, Hassink G, Barel M, Hirsch C, van der Wal F J, Wiertz E
Abstract excerpt
Human cytomegalovirus encodes two glycoproteins, US2 and US11, which cause rapid degradation of MHC class I molecules, thus preventing recognition of virus-infected cells by the immune system. This degradation process involves retrograde transport or 'dislocation' of MHC class I molecules from the endoplasmic reticulum (ER) to the cytosol, where they are deglycosylated by an N-glycanase and degraded by the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.