Article
Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites.
mBio - 28 Jun 2016
Voss Christiane, Ehrenman Karen, Mlambo Godfree, Mishra Satish, Kumar Kota Arun, Sacci John B, Sinnis Photini, Coppens Isabelle
Abstract excerpt
UNLABELLED: Plasmodium parasites undergo continuous cellular renovation to adapt to various environments in the vertebrate host and insect vector. In hepatocytes, Plasmodium berghei discards unneeded organelles for replication, such as micronemes involved in invasion. Concomitantly, intrahepatic parasites expand organelles such as the apicoplast that produce essential metabolites. We previously showed that the...
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