Article
Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
American journal of medical genetics. Part A - 1 Dec 2009
Ester Audrey R, Weymouth Katelyn S, Burt Amber, Wise Carol A, Scott Allison, Gurnett Christina A, Dobbs Matthew B, Blanton Susan H, Hecht Jacqueline T
Abstract excerpt
Clubfoot is a common birth defect that affects 135,000 newborns each year worldwide. It is characterized by equinus deformity of one or both feet and hypoplastic calf muscles. Despite numerous study approaches, the cause(s) remains poorly understood although a multifactorial etiology is generally accepted. We considered the HOXA and HOXD gene clusters and insulin-like growth factor binding protein 3 (IGFBP3) as...
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