Article
Functional Assessment of Clubfoot Associated HOXA9, TPM1, and TPM2 Variants Suggests a Potential Gene Regulation Mechanism.
Clinical orthopaedics and related research - 1 Jul 2016
Weymouth Katelyn S, Blanton Susan H, Powell Tamar, Patel Chandrashekhar V, Savill Stuart A, Hecht Jacqueline T
Abstract excerpt
BACKGROUND: Isolated nonsyndromic clubfoot is a common birth defect affecting 135,000 newborns worldwide each year. Although treatment has improved, substantial long-term morbidity persists. Genetic causes have been implicated in family-based studies but the genetic changes have eluded identification. Previously, using a candidate gene approach in our family-based dataset, we identified associations between...
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