Article
Variants in genes that encode muscle contractile proteins influence risk for isolated clubfoot.
American journal of medical genetics. Part A - 1 Sept 2011
Weymouth Katelyn S, Blanton Susan H, Bamshad Michael J, Beck Anita E, Alvarez Christine, Richards Steve, Gurnett Christina A, Dobbs Matthew B, Barnes Douglas, Mitchell Laura E, Hecht Jacqueline T
Abstract excerpt
Isolated clubfoot is a relatively common birth defect that affects approximately 4,000 newborns in the US each year. Calf muscles in the affected leg(s) are underdeveloped and remain small even after corrective treatment. This observation suggests that variants in genes that influence muscle development are priority candidate risk factors for clubfoot. This contention is further supported by the discovery that...
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