Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study identifies new disease loci for isolated clubfoot.

Journal of medical genetics - 1 May 2014

Zhang Tian-Xiao, Haller Gabe, Lin Peng, Alvarado David M, Hecht Jacqueline T, Blanton Susan H, Stephens Richards B, Rice John P, Dobbs Matthew B, Gurnett Christina A

Abstract excerpt

BACKGROUND: Clubfoot is a common congenital birth defect with complex inheritance patterns. Currently, the genetic and morphological basis of clubfoot is poorly understood. To identify genetic risk factors associated with clubfoot, we performed a genome-wide association study of common genetic variants. METHODS: The DNA of 396 isolated clubfoot patients and 1000 controls of European descent was genotyped for >600...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clubfoot

Share to Forkhead Transcription Factors

Share to Genetic Loci

Share to Matrix Metalloproteinase 7

Share to Receptors, Cell Surface

Share to Repressor Proteins

Source

Identifiers

PMID: 24667120
DOI: 10.1136/jmedgenet-2014-102303

Genes

FOXN3
MMP7
NCOR2
SORCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study identifies new disease loci for isolated clubfoot.PMID 24667120Read ↗

Whole Exome Sequencing in Individuals with Idiopathic Clubfoot Reveals a Recurrent Filamin B (FLNB) Deletion.Semantic proximity Read ↗

The genetics of isolated and syndromic clubfootSemantic proximity Read ↗

Exome sequencing of 1190 non-syndromic clubfoot cases reveals HOXD12 as a novel disease gene.Semantic proximity Read ↗

The genetics of idiopathic clubfoot.Semantic proximity Read ↗

Variants in genes that encode muscle contractile proteins influence risk for isolated clubfoot.Semantic proximity Read ↗

Prenatal isolated clubfoot increases the risk for clinically significant exome sequencing resultsSemantic proximity Read ↗

Rare and de novo duplications containing SHOX in clubfoot.Semantic proximity Read ↗

Association of Polymorphism in Locus of rs274503 (ZBED5/GALNT18) with the Risk of Idiopathic Clubfoot in Chinese Children: An 11-Center Case-Control Study.Semantic proximity Read ↗

Genetics of clubfoot; recent progress and future perspectives.Semantic proximity Read ↗

Incidence and prevalence of congenital clubfoot in Apulia: a regional model for future prospective national studiesSemantic proximity Read ↗

Genetic analysis in fetuses with isolated clubfoot: diagnostic insights and added valueSemantic proximity Read ↗

Genetics, epidemiology and management of clubfoot and related disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.