Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Huntingtin facilitates polycomb repressive complex 2

23 Nov 2009

Abstract excerpt

Huntington's disease (HD) is caused by expansion of the polymorphic polyglutamine segment in the huntingtin protein. Full-length huntingtin is thought to be a predominant HEAT repeat alpha-solenoid, implying a role as a facilitator of macromolecular complexes. Here we have investigated huntingtin's domain structure and potential intersection with epigenetic silencer polycomb repressive complex 2 (PRC2), suggested...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Neurodegenerative Diseases
Share to Traumatic Brain Injury Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19933700
DOI: 10.1093/hmg/ddp524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huntingtin facilitates polycomb repressive complex 2PMID 19933700Read ↗

Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Semantic proximity Read ↗

Hypomorphic mutation of the mouse Huntington’s disease gene orthologueSemantic proximity Read ↗

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.Semantic proximity Read ↗

ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.Semantic proximity Read ↗

A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.Semantic proximity Read ↗

Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles.Semantic proximity Read ↗

Polyglutamine (polyQ) disordersSemantic proximity Read ↗

Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation.Semantic proximity Read ↗

Evolving Notch polyQ tracts reveal possible solenoid interference elementsSemantic proximity Read ↗

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factorSemantic proximity Read ↗

The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activitiesSemantic proximity Read ↗

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.