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Article

Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms.

Investigative ophthalmology & visual science - 1 Apr 2010

Edwards Digna R Velez, Gallins Paul, Polk Monica, Ayala-Haedo Juan, Schwartz Stephen G, Kovach Jaclyn L, Spencer Kylee, Wang Gaofeng, Agarwal Anita, Postel Eric A, Haines Jonathan L, Pericak-Vance Margaret, Scott William K

Abstract excerpt

Purpose. To investigate whether female reproductive history and hormone replacement therapy (HRT) or birth control pills (BCPs) influence risk for age-related macular degeneration (AMD) and whether genetic factors interact with HRT to modulate AMD risk. Methods. Related and unrelated female participants (n = 799) were examined and data were analyzed with generalized estimating equations with adjustment for age...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19933179
DOI: 10.1167/iovs.09-4000
PMCID: PMC2868389

Genes

ARMS2

Variants

rs10490923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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