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Article

Reticular Pseudodrusen Status, ARMS2/HTRA1 Genotype, and Geographic Atrophy Enlargement: Age-Related Eye Disease Study 2 Report 32.

Ophthalmology - 1 May 2023

Agrón Elvira, Domalpally Amitha, Cukras Catherine A, Clemons Traci E, Chen Qingyu, Swaroop Anand, Lu Zhiyong, Chew Emily Y, Keenan Tiarnan D L

Abstract excerpt

PURPOSE: To determine whether reticular pseudodrusen (RPD) status, ARMS2/HTRA1 genotype, or both are associated with altered geographic atrophy (GA) enlargement rate and to analyze potential mediation of genetic effects by RPD status. DESIGN: Post hoc analysis of an Age-Related Eye Disease Study 2 cohort. PARTICIPANTS: Eyes with GA: n = 771 from 563 participants. METHODS: Geographic atrophy area was measured from...

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Identifiers

PMID: 36481221
DOI: 10.1016/j.ophtha.2022.11.026
PMCID: PMC10121754

Genes

ARMS2
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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