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Article

Unexpectedly severe acute radiotherapy side effects are associated with single nucleotide polymorphisms of the melanocortin-1 receptor.

International journal of radiation oncology, biology, physics - 1 Aug 2010

Fogarty Gerald B, Muddle Rory, Sprung Carl N, Chen Wei, Duffy David, Sturm Richard A, McKay Michael J

Abstract excerpt

PURPOSE: The melanocortin-1 receptor (MC1R) regulates melanin biogenesis. Deoxyribonucleic acid sequence variants in the form of single nucleotide polymorphisms (SNPs) of MC1R affect melanin expression and are linked to skin phenotype. We aimed to determine whether SNPs of MC1R were associated with unexpectedly severe ionizing radiation reactions. METHODS AND MATERIALS: The MC1R genotype of a cohort of...

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Source

Identifiers

PMID: 19932942
DOI: 10.1016/j.ijrobp.2009.07.1690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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