Article
Detection of genetic alterations in hereditary colorectal cancer screening.
Mutation research - 10 Nov 2010
Pineda Marta, González Sara, Lázaro Conxi, Blanco Ignacio, Capellá Gabriel
Abstract excerpt
There are two major hereditary colorectal cancer syndromes: Adenomatous Polyposis, secondary to APC germline alterations (FAP, Familial Adenomatous Polyposis) or secondary to MUTYH germline alterations (MAP, MUTYH associated Polyposis), and Lynch syndrome, associated with germline mutations in mismatch repair genes (MLH1, MSH2, MSH6 and PMS2). The elucidation of their genetic basis has depicted an increasingly...
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