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Article

Fhl5/Act, a CREM-binding transcriptional activator required for normal sperm maturation and morphology, is not essential for testicular gene expression.

Reproductive biology and endocrinology : RB&E - 24 Nov 2009

Lardenois Aurélie, Chalmel Frédéric, Demougin Philippe, Kotaja Noora, Sassone-Corsi Paolo, Primig Michael

Abstract excerpt

BACKGROUND: The LIM domain protein Fhl5 was previously found to interact with CREM, a DNA binding transcriptional regulator necessary for spermiogenesis in mammals. Co-transfection experiments using heterologous promoter constructs indicated a role for Fhl5 in transcriptional up-regulation of CRE...

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Identifiers

PMID: 19930692
DOI: 10.1186/1477-7827-7-133
PMCID: PMC2788571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19930692-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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