Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency.

Human molecular genetics - 1 Jul 2011

Bouhali Kamal, Dipietromaria Aurélie, Fontaine Anastasia, Caburet Sandrine, Barbieri Ottavia, Bellessort Brice, Fellous Marc, Veitia Reiner A, Levi Giovanni

Abstract excerpt

Primary ovarian insufficiency (POI) is characterized by the loss of ovarian function before the age of 40 in humans. Although most cases of POI are idiopathic, many are familial, underlying a genetic origin of the disease. Mutations in genes involved in the control of steroidogenesis, such as NR5A1 (SF-1, Steroidogenic Factor 1), CYP17, CYP19A1 (aromatase), StAR (Steroidogenic Acute Regulatory), and the forkhead...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fertility
Share to Forkhead Box Protein L2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Gene Order

Share to Granulosa Cells

Share to Homeodomain Proteins

Share to Ovarian Follicle

Share to Primary Ovarian Insufficiency

Source

Identifiers

PMID: 21505076
DOI: 10.1093/hmg/ddr166

Genes

FOXL2
GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic reduction of Dlx5 and Dlx6 results in early follicular depletion: a new mouse model of primary ovarian insufficiency.PMID 21505076Read ↗

Positive Regulation of Steroidogenic Acute Regulatory Protein Gene Expression through the Interaction between Dlx and GATA-4 for Testicular SteroidogenesisSemantic proximity Read ↗

<i>Nr5a1</i> suppression during the fetal period optimizes ovarian development by fine-tuning of Notch signalingSemantic proximity Read ↗

Steroidogenic Factor 1 Differentially Regulates Fetal and Adult Leydig Cell Development in Male Mice1Semantic proximity Read ↗

Steroidogenic factor 1: an essential mediator of endocrine development.Semantic proximity Read ↗

Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells.Semantic proximity Read ↗

NR5A1/SF-1 and development and function of the ovary.Semantic proximity Read ↗

Steroidogenic factor 1 (SF-1; Nr5a1 ) regulates the formation of the ovarian reserveSemantic proximity Read ↗

DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual DifferentiationSemantic proximity Read ↗

[SF-1, a key player in adrenal and gonadal differentiation: implications in gonadal dysgenesis and primary ovarian insufficiency].Semantic proximity Read ↗

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogoniaSemantic proximity Read ↗

In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal glandSemantic proximity Read ↗

Cell-Specific Knockout of Steroidogenic Factor 1 Reveals Its Essential Roles in Gonadal FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.