Article
Are HLA DQB1 alleles correlated with breast cancer histopronostic parameters in Tunisia?
La Tunisie medicale - 1 Jun 2009
Baccar Amal, Loueslati Besma Yacoubi, Troudi Wafa, Hmida Slama, Dridi Amel, Jridi Afef, Mrad Karima, Ben Romdhane Khaled, Ben Ammar Elgaaied Amel
Abstract excerpt
BACKGROUND: Tumor cells express surface structures different from normal cells. These structures may be recognized by the immune system, which ensure anti-tumoral surveillance. Antigenic presentation requires HLA molecules role. Since, these molecules are encoded by a high polymorphic system, immune response can be modulated according to HLA genotype. So, HLA polymorphism could be correlated with tumor escape...
Topics
- Adult
- Aged
- Alleles
- Breast Neoplasms
- Female
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Humans
- Middle Aged
- Polymorphism, Genetic
- Prognosis
- Tunisia