Article
High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates.
AIDS (London, England) - 13 Mar 2010
Verheyen Jens, Verhofstede Chris, Knops Elena, Vandekerckhove Linos, Fun Axel, Brunen Diede, Dauwe Kenny, Wensing Annemarie M J, Pfister Herbert, Kaiser Rolf, Nijhuis Monique
Abstract excerpt
OBJECTIVE: Bevirimat is the first drug of a new class of antivirals that hamper the maturation of HIV. The objective of this study was to evaluate the sequence variability of the gag region targeted by bevirimat in HIV subtype-B isolates. METHODS: Of 484 HIV subtype-B isolates, the gag region com...
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