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Article

Influence of PARP-1 polymorphisms in patients after traumatic brain injury.

Journal of neurotrauma - 1 Mar 2010

Sarnaik Ajit A, Conley Yvette P, Okonkwo David O, Barr Taura L, Fink Ericka L, Szabo Csaba, Kochanek Patrick M, Clark Robert S B

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in the cellular response to stress and DNA damage. However, excessive activity of PARP-1 exacerbates brain injury via NAD+ depletion and energy failure. The purpose of this study was to determine if tagging single nucleotide polymorph...

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Source

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Identifiers

PMID: 19925161
DOI: 10.1089/neu.2009.1171
PMCID: PMC2867630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19925161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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