Article
XPC gene variants: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy.
Journal of cancer research and clinical oncology - 1 May 2010
Gangwar Ruchika, Mandhani Anil, Mittal Rama Devi
Abstract excerpt
PURPOSE: To investigate the association between two Xeroderma pigmentosum group C polymorphism (XPC Lys939Gln and insertion/deletion PAT -/+ in intron 9) and bladder cancer (BC) susceptibility. MATERIALS AND METHODS: Genotyping was performed in 208 BC patients and 245 controls by PCR-RFLP method. RESULTS: XPC PAT +/+ genotype was associated with elevated risk of BC (p = 0.021, OR = 2.49). XPC Lys939Gln AC + CC...
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