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Article

Quaternary structure of KATP channel SUR2A nucleotide binding domains resolved by synchrotron radiation X-ray scattering.

Journal of structural biology - 1 Feb 2010

Park Sungjo, Terzic Andre

Abstract excerpt

Heterodimeric nucleotide binding domains NBD1/NBD2 distinguish the ATP-binding cassette protein SUR2A, a recognized regulatory subunit of cardiac ATP-sensitive K(+) (K(ATP)) channels. The tandem function of these core domains ensures metabolism-dependent gating of the Kir6.2 channel pore, yet their structural arrangement has not been resolved. Here, purified monodisperse and interference-free recombinant...

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Share to Circular Dichroism
Share to Microscopy, Atomic Force
Share to Potassium Channels, Inwardly Rectifying

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Quaternary

Share to Receptors, Drug

Share to Scattering, Small Angle

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Identifiers

PMID: 19919849
DOI: 10.1016/j.jsb.2009.11.005
PMCID: PMC2818519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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