Article
Potassium channel regulation.
EMBO reports - 1 Nov 2003
Campbell Jeff D, Sansom Mark S P, Ashcroft Frances M
Abstract excerpt
The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis of these functional...
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