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Article

Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor.

The Journal of biological chemistry - 31 Oct 2008

Masia Ricard, Nichols Colin G

Abstract excerpt

ATP-sensitive K(+) (K(ATP)) channels modulate their activity as a function of inhibitory ATP and stimulatory Mg-nucleotides. They are constituted by two proteins: a pore-forming K(+) channel subunit (Kir6.1, Kir6.2) and a regulatory sulfonylurea receptor (SUR) subunit, an ATP-binding cassette (ABC) transporter that confers MgADP stimulation to the channel. Channel regulation by MgADP is dependent on nucleotide...

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Share to Adenosine Diphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18715873
DOI: 10.1074/jbc.M804318200
PMCID: PMC2662084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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