Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects.

Matrix biology : journal of the International Society for Matrix Biology - 1 Aug 2002

Dozin Beatrice, Malpeli Mara, Camardella Laura, Cancedda Ranieri, Pietrangelo Antonello

Abstract excerpt

The aim of this study was to investigate the metabolic properties of human articular chondrocytes derived from young, aged and osteoarthritic subjects and their genetic adaptation to a catabolic challenge (i.e. the inflammatory cytokines interleukin-1alpha and tumor necrosis factor-alpha), in the absence or presence of diacerein, a drug potentially useful in osteoarthritis. Chondrocytes in primary culture were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthraquinones
Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cartilage, Articular

Share to Chitinases

Share to Chondrocytes

Share to Interleukin-1

Share to Metalloendopeptidases

Share to Osteoarthritis

Source

Identifiers

PMID: 12225810
DOI: 10.1016/s0945-053x(02)00028-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects.PMID 12225810Read ↗

Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.Semantic proximity Read ↗

[Chondrocytes secretory phenotype associated with aging: role in the pathogenesis of osteoarthritis and prospects for peptide bioregulation.]Semantic proximity Read ↗

Transcriptome Analysis of Injured Human Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration With AgingSemantic proximity Read ↗

In vitro phenotypic modulation of chondrocytes from knees of patients with osteochondritis dissecans: implications for chondrocyte implantation procedures.Semantic proximity Read ↗

Gene expression profiling of serum- and interleukin-1β-stimulated primary human adult articular chondrocytes – A molecular analysis based on chondrocytes isolated from one donorSemantic proximity Read ↗

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilageSemantic proximity Read ↗

Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype.Semantic proximity Read ↗

Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1betaSemantic proximity Read ↗

Pannocytes: distinctive cells found in rheumatoid arthritis articular cartilage erosions.Semantic proximity Read ↗

Dedifferentiated chondrocytes cultured in alginate beads: restoration of the differentiated phenotype and of the metabolic responses to interleukin-1beta.Semantic proximity Read ↗

Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases.Semantic proximity Read ↗

[Arthritis from a biochemical aspect].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.