Article
Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation.
The Journal of clinical investigation - 1 Feb 1991
Perdue M H, Masson S, Wershil B K, Galli S J
Abstract excerpt
To investigate the role of mast cells in transport abnormalities during intestinal anaphylaxis, we examined responses to antigen in isolated intestinal preparations from ovalbumin-sensitized genetically mast cell-deficient WBB6F1-W/Wv (W/Wv) mice and congenic normal WBBGF1(-)+/+ (+/+) mice. Changes in ion transport (primarily secretion of chloride ions) were indicated by increases in short-circuit current (Isc)....
Topics
- Anaphylaxis
- Animals
- Biological Transport
- Bone Marrow Transplantation
- Diphenhydramine
- In Vitro Techniques
- Intestinal Diseases
- Intestinal Mucosa
- Mast Cells
- Mice