Pertussis toxin stimulates hypersensitivity and enhances nerve-mediated antigen uptake in rat intestine.

doi:10.1152/ajpgi.1994.267.5.G745

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Article

Pertussis toxin stimulates hypersensitivity and enhances nerve-mediated antigen uptake in rat intestine.

The American journal of physiology - 1 Nov 1994

Kosecka U, Marshall J S, Crowe S E, Bienenstock J, Perdue M H

Abstract excerpt

We previously reported that intestine from rats sensitized to ovalbumin (Ova), using Bordetella pertussis vaccine as adjuvant, demonstrated a rapid secretory response [increase in short-circuit current (Isc)] to Ova upon secondary challenge. Here, we examined the role of pertussis toxin, the active component of the vaccine, in the response. Sensitization of Sprague-Dawley rats by intraperitoneal injection of...

Topics

Animals
Antibodies
Antigens
Hypersensitivity
Immunization
Immunoglobulin E
Immunoglobulin G
Intestinal Mucosa
Intestines
Male
Mast Cells
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nervous System Physiological Phenomena

Ovalbumin

Pertussis Toxin

Rats

Rats, Sprague-Dawley

Transcutaneous Electric Nerve Stimulation

Source

Open in PubMed

Identifiers

PMID: 7977735
DOI: 10.1152/ajpgi.1994.267.5.G745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7977735-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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