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Article

Th17-lineage cells in pulmonary sarcoidosis and Löfgren's syndrome: Friend or foe?

Journal of autoimmunity - 1 Feb 2018

Miedema Jelle R, Kaiser Ylva, Broos Caroline E, Wijsenbeek Marlies S, Grunewald Johan, Kool Mirjam

Abstract excerpt

Sarcoidosis, a multisystem granulomatous disorder, has historically been classified as Th1-driven disease. However, increasing data demonstrate a key role of Th17-cell plasticity in granuloma formation and maintenance. In Löfgren's syndrome (LS), an acute and distinct phenotype of sarcoidosis with a favorable outcome, differences in Th17-lineage cell subsets, cytokine expression and T-cell suppressive mechanisms...

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Identifiers

PMID: 29310925
DOI: 10.1016/j.jaut.2017.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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