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Article

Targeting oncogenic Raf protein-serine/threonine kinases in human cancers.

Pharmacological research - 1 Sept 2018

Roskoski Robert

Abstract excerpt

The Ras-Raf-MEK-ERK signal transduction cascade is arguably the most important oncogenic pathway in human cancers. Ras-GTP promotes the formation of active homodimers or heterodimers of A-Raf, B-Raf, and C-Raf by an intricate process. These enzymes are protein-serine/threonine kinases that catalyze the phosphorylation and activation of MEK1 and MEK2 which, in turn, catalyze the phosphorylation and activation of...

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Source

Identifiers

PMID: 30118796
DOI: 10.1016/j.phrs.2018.08.013

Genes

BRAF
KRAS
KSR1
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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