BRAFV600E: implications for carcinogenesis and molecular therapy.

doi:10.1158/1535-7163.MCT-10-0799

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Article

BRAFV600E: implications for carcinogenesis and molecular therapy.

Molecular cancer therapeutics - 1 Mar 2011

Cantwell-Dorris Emma R, O'Leary John J, Sheils Orla M

Abstract excerpt

The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is frequently mutated in human cancer. This pathway consists of a small GTP protein of the RAS family that is activated in response to extracellular signaling to recruit a member of the RAF kinase family to the cell membrane. Active RAF signals through MAP/ERK kinase to activate ERK and its downstream effectors to...

Topics

Animals
Cell Transformation, Neoplastic
Extracellular Signal-Regulated MAP Kinases
Humans
Mice
Mitogen-Activated Protein Kinases
Molecular Targeted Therapy
Mutation
Proto-Oncogene Proteins B-raf

Source

Open in PubMed

Identifiers

PMID: 21388974
DOI: 10.1158/1535-7163.MCT-10-0799

Genes

BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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