Article
Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts.
Neuro-degenerative diseases - 1 Jan 2006
Fung H C, Xiromerisiou G, Gibbs J R, Wu Y R, Eerola J, Gourbali V, Hellström O, Chen C M, Duckworth J, Papadimitriou A, Tienari P J, Hadjigeorgiou G M, Hardy J, Singleton A B
Abstract excerpt
BACKGROUND: The overlap in the clinical and pathological features of tauopathies and synucleinopathies raises the possibility that the tau protein may be important in Parkinson's disease (PD) pathogenesis. Several MAPT polymorphisms that define the tau H1 haplotype have been investigated for an association with PD with conflicting results; however, two meta-analyses support an association between haplotype H1 and...
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