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Article

A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

3 Oct 2005

Abstract excerpt

HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target of the fusion-inhibitor drug enfuvirtide (T20). The HR1 sequence is highly conserved and therefore considered an attractive target for vaccine development, but it is unknown whether antibodies can access HR1. Herein,...

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Identifiers

PMID: 16203977
DOI: 10.1073/pnas.0506927102

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