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Article

Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling.

The Journal of biological chemistry - 8 Jan 2010

Orba Yasuko, Suzuki Tadaki, Makino Yoshinori, Kubota Kanako, Tanaka Shinya, Kimura Takashi, Sawa Hirofumi

Abstract excerpt

Large T antigen (TAg) of the human polyomavirus JC virus (JCV) possesses DNA binding and helicase activities, which, together with various cellular proteins, are required for replication of the viral genome. We now show that JCV-infected cells expressing TAg accumulate in the G(2) phase of the ce...

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Topics

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Share to Antigens, Viral, Tumor
Share to CDC2 Protein Kinase
Share to Checkpoint Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin B

Share to G2 Phase

Share to JC Virus

Share to Oligodendroglia

Share to Polyomavirus Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 19903823
DOI: 10.1074/jbc.M109.064311
PMCID: PMC2801279

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19903823-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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