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Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins

13 Feb 2006

Abstract excerpt

The DNA damage checkpoint pathway responds to DNA damage and induces a cell cycle arrest to allow time for DNA repair. Several viruses are known to activate or modulate this cellular response. Here we show that the ataxia-telangiectasia mutated checkpoint pathway, which responds to double-strand breaks in DNA, is activated in response to human cytomegalovirus DNA replication. However, this activation does not...

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Identifiers

PMID: 16477038
DOI: 10.1073/pnas.0511148103

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