Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003

Daniel René, Kao Gary, Taganov Konstantin, Greger James G, Favorova Olga, Merkel George, Yen Tim J, Katz Richard A, Skalka Anna Marie

Abstract excerpt

Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases. Here, we show that caffeine treatment causes a dose-dependent reduction in the total amount of HIV-1 and avian sarcoma virus retroviral vector DNA that is joined to host DNA in the population of infected cells and also in the number of transduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Avian Sarcoma Viruses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caffeine

Share to HIV Integrase

Share to Lac Operon

Share to Retroviridae

Share to Transduction, Genetic

Share to Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 12679521
DOI: 10.1073/pnas.0730887100
PMCID: PMC153632

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.PMID 12679521Read ↗

DNA Damage Sensors ATM, ATR, DNA-PKcs, and PARP-1 Are Dispensable for Human Immunodeficiency Virus Type 1 IntegrationSemantic proximity Read ↗

The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral IntegrationSemantic proximity Read ↗

DNA viruses and the cellular DNA-damage responseSemantic proximity Read ↗

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response ProteinsSemantic proximity Read ↗

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repairSemantic proximity Read ↗

Induction and Utilization of an ATM Signaling Pathway by PolyomavirusSemantic proximity Read ↗

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA ReplicationSemantic proximity Read ↗

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agentsSemantic proximity Read ↗

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.Semantic proximity Read ↗

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.Semantic proximity Read ↗

SV40 Utilizes ATM Kinase Activity to Prevent Non-homologous End Joining of Broken Viral DNA Replication ProductsSemantic proximity Read ↗

ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin ReplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.