Article
Leukocyte adhesion deficiency type II.
Biochimica et biophysica acta - 8 Oct 1999
Becker D J, Lowe J B
Abstract excerpt
Leukocyte adhesion deficiency type II (LAD II) is a rare disorder characterized by recurrent infections, persistent leukocytosis, and severe mental and growth retardation. LAD II neutrophils are deficient in expression of selectin ligand activity, and exhibit a correspondingly diminished ability to roll on endothelium and to traffic to inflammatory sites in vivo. LAD II patients exhibit a deficiency in the...
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