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Article

Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3(+) T cells.

Brain, behavior, and immunity - 1 Mar 2015

González Florencia B, Villar Silvina R, Fernández Bussy Rodrigo, Martin Gaëlle H, Pérol Louis, Manarin Romina, Spinelli Silvana V, Pilon Caroline, Cohen José Laurent, Bottasso Oscar A, Piaggio Eliane, Pérez Ana R

Abstract excerpt

We previously showed that Trypanosomacruzi infection in C57BL/6 mice results in a lethal infection linked to unbalanced pro- and anti-inflammatory mediators production. Here, we examined the dynamics of CD4(+)Foxp3(+) regulatory T (Treg) cells within this inflammatory and highly Th1-polarized environment. Treg cells showed a reduced proliferation rate and their frequency is progressively reduced along infection...

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Identifiers

PMID: 25483139
DOI: 10.1016/j.bbi.2014.11.016
PMCID: PMC7126853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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