Article
A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression.
AIDS (London, England) - 10 Sept 2009
Tso For Yue, Hoffmann Federico G, Tully Damien C, Lemey Philippe, Rasmussen Robert A, Zhang Hong, Ruprecht Ruth M, Wood Charles
Abstract excerpt
OBJECTIVE: To evaluate whether HIV-1 clade C (HIV-C) envelope variations that arise during disease progression in rhesus macaque model reflect changes that occur naturally in human infection. DESIGN: An infant macaque was infected with SHIV-1157i, an R5 tropic clade C SHIV, that expresses a primary HIV-C envelope derived from an infected human infant and monitored over a 5-year period. Genetic variation of the...
Topics
- Amino Acid Sequence
- Animals
- CD4 Lymphocyte Count
- Disease Progression
- Evolution, Molecular
- Genetic Variation
- Glycosylation
- HIV Infections
- HIV-1
- Humans
- Infant
- Macaca mulatta
- Molecular Sequence Data