Article
V3 sequences of paired HIV-1 isolates from blood and cerebrospinal fluid cluster according to host and show variation related to the clinical stage of disease.
Virology - 1 Oct 1993
Keys B, Karis J, Fadeel B, Valentin A, Norkrans G, Hagberg L, Chiodi F
Abstract excerpt
The spread of HIV-1 to the nervous system occurs early during infection in a large number of asymptomatic virus carriers. In order to address the question whether the brain is targeted by a group of HIV-1 variants with increased neurotropic properties we have obtained 20 paired isolates from the...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Blood
- Cerebrospinal Fluid
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Humans
- Macrophages
- Molecular Sequence Data
- Monocytes
- Sequence Homology, Amino Acid
- Time Factors
- Tissue Distribution