Article
Detection of isoniazid and rifampicin resistance by sequencing of katG, inhA, and rpoB genes in Korea.
The Korean journal of laboratory medicine - 1 Oct 2009
Cho Eun Hae, Bae Hye Kyung, Kang Seong Ki, Lee Eun Hee
Abstract excerpt
BACKGROUND: In Korea, tuberculosis is resistant to isoniazid (INH) and/or rifampicin (RIF) in more than 10% of cases. To prevent the spread of resistant Mycobacterium tuberculosis strains, it is crucial to develop more rapid resistance detection methods. METHODS: To determine the feasibility of using direct sequencing for detecting INH- and RIF-resistant strains, the katG gene, the regulatory region of the inhA...
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