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Article

Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study.

Aging - 1 Jul 2016

Koopman Jacob J E, Pijpe Jeroen, Böhringer Stefan, van Bodegom David, Eriksson Ulrika K, Sanchez-Faddeev Hernando, Ziem Juventus B, Zwaan Bas, Slagboom P Eline, de Knijff Peter, Westendorp Rudi G J

Abstract excerpt

Human survival probability and fertility decline strongly with age. These life history traits have been shaped by evolution. However, research has failed to uncover a consistent genetic determination of variation in survival and fertility. As an explanation, such genetic determinants have been selected in adverse environments, in which humans have lived during most of their history, but are almost exclusively...

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PMID: 27356285
DOI: 10.18632/aging.100986
PMCID: PMC4993336

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