Article
CFTR mutations and reproductive outcomes in a population isolate.
Human genetics - 1 Jan 2008
Gallego Romero Irene, Ober Carole
Abstract excerpt
Multiple hypotheses have been proposed to explain the high incidence of cystic fibrosis in Caucasian populations. Most rely on a fitness advantage to carriers of CF mutations, either through increased resistance to infectious disease, such as cholera, or through increased fertility. In this study we tested the latter hypothesis in the Hutterites of South Dakota, a genetic isolate with a relatively high CF carrier...
Topics
- Child
- Cystic Fibrosis Transmembrane Conductance Regulator
- Family
- Female
- Fertility
- Gene Frequency
- Genetic Carrier Screening
- Genetics, Population
- Genotype
- Humans
- Inheritance Patterns
- Male
- Mutation
- Reproduction
- Social Isolation