Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways <i>in vivo</i>

2 Nov 2009

Abstract excerpt

Attaching and effacing (A/E) lesions and actin polymerization, the hallmark of enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC) and Citrobacter rodentium (CR) infections, are dependent on the effector Tir. Phosphorylation of Tir(EPEC/CR) Y474/1 leads to recruitment of Nck and neural Wiskott-Aldrich syndrome protein (N-WASP) and strong actin polymerization in cultured cells. Tir(EPEC/CR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Genetics and Biotechnology
Share to Escherichia coli research studies
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19889090
DOI: 10.1111/j.1365-2958.2009.06938.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways <i>in vivo</i>PMID 19889090Read ↗

Intimate host attachment: enteropathogenic and enterohaemorrhagic<i>Escherichia coli</i>Semantic proximity Read ↗

Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection.Semantic proximity Read ↗

Exploitation of host cells by enteropathogenic <i>Escherichia</i> <i>coli</i>Semantic proximity Read ↗

EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly.Semantic proximity Read ↗

The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)Semantic proximity Read ↗

The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologueSemantic proximity Read ↗

Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.Semantic proximity Read ↗

GBP1 recruitment to actin-rich pedestals induced by extracellular Gram-negative bacteria promotes pyroptosisSemantic proximity Read ↗

Attaching and effacing bacterial pathogenesis : characterisation of a severe disease model and the role of effector protein MapSemantic proximity Read ↗

Simultaneous inactivation of espB and tir abrogates the strong, but non-protective, inflammatory response induced by EPEC.Semantic proximity Read ↗

Enteropathogenic Escherichia coli (EPEC) attachment to epithelial cells: exploiting the host cell cytoskeleton from the outsideSemantic proximity Read ↗

A <i>Caenorhabditis elegans nck-1</i> and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.