Article
Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection.
Helicobacter - 1 Dec 2009
Hung Kuei-Hsiang, Hung Hunt-Wen, Yang Hsiao-Bai, Lu Cheng-Chan, Wu Jiunn-Jong, Sheu Bor-Shyang
Abstract excerpt
BACKGROUND: Helicobacter pylori infection causes chronic gastric inflammation and intestinal metaplasia (IM), related with deregulation of Wnt pathway and over-expressions of COX-2, matrix metalloproteinase (MMP), and tissue inhibitors of matrix metalloproteinase (TIMP). We thus test the host genomic predispositions related to the risk of IM after H. pylori infection. METHODS: We enrolled 296 H. pylori-infected...
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