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Contributions of Tissue Inhibitor of Metalloproteinase-1 Genotypes to the Risk of Metastasis in Gastric Cancer.

Anticancer research - 1 Nov 2024

Fu Chun-Kai, Lee Hsu-Tung, Chen Jaw-Chyun, Yang Mei-Due, Cheng Hsu-Chen, Mong Mei-Chin, Tsai Chia-Wen, Chang Wen-Shin, Hung Yi-Chih, Bau DA-Tian

Abstract excerpt

BACKGROUND/AIM: In gastric cancer (GCa) tissues, the mRNA and protein levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) are significantly elevated compared to adjacent non-cancerous tissues. Moreover, the abnormal up-regulation of TIMP-1 has been associated with a poor prognosis. However, the role of TIMP-1 genotypes in susceptibility to GCa has seldom been investigated. This study aimed to evaluate the...

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Case-Control Studies
Helicobacter Infections
Neoplasm Metastasis
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Stomach Neoplasms

Tissue Inhibitor of Metalloproteinase-1

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PMID: 39477311
DOI: 10.21873/anticanres.17309

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