Rapid amplification of a retrotransposon subfamily is evolving the mouse genome.

doi:10.1038/3104

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Article

Rapid amplification of a retrotransposon subfamily is evolving the mouse genome.

Nature genetics - 1 Nov 1998

DeBerardinis R J, Goodier J L, Ostertag E M, Kazazian H H

Abstract excerpt

Retrotransposition affects genome structure by increasing repetition and producing insertional mutations. Dispersion of the retrotransposon L1 throughout mammalian genomes suggests that L1 activity might be an important evolutionary force. Here we report that L1 retrotransposition contributes to rapid genome evolution in the mouse, because a number of L1 sequences from the T(F) subfamily are retrotransposition...

Topics

5' Untranslated Regions
Animals
Evolution, Molecular
Gene Amplification
Genome
Humans
Mice
Molecular Sequence Data
Mutation
Polymorphism, Genetic
Retroelements
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 9806550
DOI: 10.1038/3104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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