Article
Structure and function of the PLAA/Ufd3-p97/Cdc48 complex.
The Journal of biological chemistry - 1 Jan 2010
Qiu Liyan, Pashkova Natasha, Walker John R, Winistorfer Stanley, Allali-Hassani Abdellah, Akutsu Masato, Piper Robert, Dhe-Paganon Sirano
Abstract excerpt
PLAA (ortholog of yeast Doa1/Ufd3, also know as human PLAP or phospholipase A2-activating protein) has been implicated in a variety of disparate biological processes that involve the ubiquitin system. It is linked to the maintenance of ubiquitin levels, but the mechanism by which it accomplishes this is unclear. The C-terminal PUL (PLAP, Ufd3p, and Lub1p) domain of PLAA binds p97, an AAA ATPase, which among other...
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