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Article

Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain.

Molecular and cellular biology - 1 Feb 2006

Mullally James E, Chernova Tatiana, Wilkinson Keith D

Abstract excerpt

Cdc48 (p97/VCP) is an AAA-ATPase molecular chaperone whose cellular functions are facilitated by its interaction with ubiquitin binding cofactors (e.g., Npl4-Ufd1 and Shp1). Several studies have shown that Saccharomyces cerevisiae Doa1 (Ufd3/Zzz4) and its mammalian homologue, PLAA, interact with...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16428438
DOI: 10.1128/MCB.26.3.822-830.2006
PMCID: PMC1347030

Genes

PLAA
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16428438-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain.PMID 16428438Read ↗

Structure and function of the PLAA/Ufd3-p97/Cdc48 complex.Semantic proximity Read ↗

The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism.Semantic proximity Read ↗

Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.Semantic proximity Read ↗

Cdc48: A Swiss Army Knife of Cell BiologySemantic proximity Read ↗

An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation.Semantic proximity Read ↗

DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies.Semantic proximity Read ↗

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.Semantic proximity Read ↗

Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.Semantic proximity Read ↗

The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast.Semantic proximity Read ↗

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.Semantic proximity Read ↗

A complex of mammalian Ufd1 and Npl4 links the AAA‐ATPase, p97, to ubiquitin and nuclear transport pathwaysSemantic proximity Read ↗

Control of p97 function by cofactor binding.Semantic proximity Read ↗

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