A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.

doi:10.1016/j.redox.2018.01.011

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Article

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.

Redox biology - 1 May 2018

Ebersoll Samantha, Musunda Blessing, Schmenger Torsten, Dirdjaja Natalie, Bonilla Mariana, Manta Bruno, Ulrich Kathrin, Comini Marcelo A, Krauth-Siegel R Luise

Abstract excerpt

Trypanosoma brucei glutaredoxin 2 (Grx2) is a dithiol glutaredoxin that is specifically located in the mitochondrial intermembrane space. Bloodstream form parasites lacking Grx2 or both, Grx2 and the cytosolic Grx1, are viable in vitro and infectious to mice suggesting that neither oxidoreductase is needed for survival or infectivity to mammals. A 37 °C to 39 °C shift changes the cellular redox milieu of...

Topics

Adaptation, Physiological
Adenosine Triphosphate
Alleles
Animals
Catalytic Domain
Cell Proliferation
Cytosol
Glutaredoxins
Hot Temperature
Humans
Mice
Mitochondria
Mitochondrial Membranes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oxidation-Reduction

Trypanosoma brucei brucei

Trypanosomiasis, African

Source

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Identifiers

PMID: 29413965
DOI: 10.1016/j.redox.2018.01.011
PMCID: PMC5975080

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